Dimethylglycine (commonly known as DMG) is classified as a food substance rather than.Dimethylglycine (DMG) and trimethylglycine (TMG) are both derivatives of the amino acid glycine and have been posited to reduce lactic acid, enhance oxygen use, and reduce seizure activity during times of stress. What we know about ASD Table 1Are there any harmful side effects associated with this treatment. Right now this is a development that is still being studied, so it is uncertain what long term effects of autistic children on a Choose article section. In fact, it was shown that the autistic children in the study did have a lower frustration level as well as a marked increase in their speaking and even cognitive abilities.Thus, each pediatrician typically will follow one affected child, if not more. To advise families, pediatricians need to be knowledgeable about the efficacy and side effects of these therapies.Autistic spectrum disorders (ASD) are thought to occur in at least one in every 1,000 children. Levy, MDVitamins and supplements, special diets, and other nontraditional treatments for ASD are becoming increasingly popular. DecemDestiny 2 Evaluating studies of psychopharmacologic therapiesBy Susan L.Complementary and alternative therapies offer other options. Practitioners may also use medications to manage hyperactivity, perseverative behaviors, obsessions, or anxiety, but these treatments should not replace the educational and behavioral interventions. Although improvements may be dramatic, complete resolution of symptoms is rare. Several disorder-specific strategies are effective in enhancing skill development and diminishing undesired behaviors.Parents interested in a CAM therapy can obtain important information from other parents, the media, and the Internet. Multiple simultaneous interventions are likely to confound the impact of additional treatments. It is useful to compare a treatment with placebo since time and the perception of treatment efficacy may affect reported outcome. These theories have spawned a wealth of treatments based on complementary and alternative medicine (CAM).The classic approach to assessing the efficacy of a particular therapy is to apply specific criteria to research reports (Table 1), 4 as has been done in studies of many treatments for ASD that are discussed below. 3 Many untested theories have emerged that purport to explain the core symptoms as well as associated medical conditions. 2 Animal data and observation of medication responses have implicated neurochemical abnormalities and provided the basis for pharmacotherapeutic trials.
Subjects should be diagnosed in a standardized manner, using standard tools. The placebo effect can be potent.Using comparable subjects helps to eliminate confounding factors. The placebo should be as similar as possible to the active compound in appearance, taste, and other attributes. Pediatricians can learn more about ASD and treatment options from the sources in Table 3.Data can be skewed by selective enrollment or by using volunteers with particular beliefs or characteristicsTo be statistically valid, data must be based on an adequate number of subjectsWhen the parent, patient, and assessment team do not know the intervention, outcome data cannot be tainted by opinionThe behavioral effects that are expected to change must be measured with objective tools and documentedInterpretation of the results requires comparison of the treatment groups in a way that can be interpreted by other scientists and that does not minimize or overstate the meaning of observed outcomesA placebo is necessary to compare the effects of active treatment to the treatment situation alone. In trying one of these therapies, the physician and parent need to establish and maintain a dialogue so that the practitioner can evaluate treatment efficacy and monitor potential side effects (Table 2). 6 Costs of such one-on-one interventions can range from $20,000 to $70,000 a year.CAM treatments that currently are popular can be categorized in several groups: vitamins and supplements, dietary manipulations, alternative uses of biologic agents, immune therapy, and nonpharmacologic therapies. Indeed, the Guideline Technical Report: Autism/Pervasive Developmental Disorders, an evidence-based literature review, advocates behaviorally based interventions. 5Although other experts in the education of children with autism have expressed concern that subjects were not randomly assigned in this study, additional studies present strong evidence that a behavioral approach effectively teaches young children with autism. At follow-up at 7 and 11 years of age, nine of the 19 children were in regular education classes and had typical cognitive skills for their age. In a controversial study by Lovaas and colleagues, 19 children under 3 years of age with autism participated in an individual, home-based program for 40 hours a week. 7 Although the study used only a small sample, the data it generated, using an objective outcome measure, suggest that high-dose vitamin C therapy may diminish stereotypic behaviors. One study examined vitamin C because of scientific evidence that it inhibits central dopamine action, which may be abnormally increased in ASD. Advocates of this type of therapy suggest that vitamins enhance neurotransmitter actions by increasing availability of substrate or cofactors.Vitamin C (ascorbic acid). System requirements for ms word 2008 for macResults of efficacy studies have varied. Advocates suggest administration of B 6 in combination with magnesium to increase clinical response. Some observers have advocated supplementation with B 6 (pyridoxine) because of its role in the generation of several neurotransmitters (serotonin, dopamine, gamma amino butyric acid, norepinephrine, and epinephrine). This potentially promising intervention needs replication with a larger sample.Vitamin B 6 and magnesium. Most of those whose behavior improved relapsed within one to six weeks after discontinuing therapy. 8 A review of 12 studies noted that about half the subjects improved within a few weeks, according to a variety of behavioral indices.
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